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ST 1.1 –
Dosimetría interna
Disertación: Giussani, Augusto
THE CURE PROJECT: INTEGRATING BIOLOGY, DOSIMETRY AND
EPIDEMIOLOGY FOR EVALUATING RADIATION EFFECTS AND
HEALTH RISKS IN CASE OF INTERNAL EXPOSURES
Giussani, Augusto
1
*; Blanchardon, Eric
2
, Gomolka, Maria
1
;
Haylock, Richard
3
Laurent, Olivier
2
; Laurier, Dominique
2
1
BfS - Federal Office for Radiation Protection, Oberschleißheim, Germany.
2
IRSN - Institute for Radiological Protection and Nuclear Safety, Fontenay-aux-Roses, France.
3
Public Health England, Chilton, United Kingdom.
*Responsible author, email: agiussani@bfs.de
Many exposure situations (occupational, post-accidental, natural radioactivity) involve internal
contamination by different radionuclides. Indeed, the major contribution to the radiation dose to
the general population is from internal exposure.
The quantification of the health effects of internal contamination is therefore one of the major
cross-cutting issues considered in the frame of the European Network of Excellence DoReMi
(EU FP7). Studies of internal contamination are also directly pertinent to the better
understanding of the impact of differing qualities of radiation and require a close collaboration
between epidemiologists, dosimetrists, toxicologists and biologists.
The CURE project was an 18-month “concerted action” supported in the frame of DoReMi and
comprised nine European partners. It began in July 2013 and ended in December 2014. This
project brought together competences in epidemiology, biology and dosimetry in Europe to
address the issue of workers exposed to uranium (miners and nuclear industry employees
involved in the uranium cycle) in which both cancer and non-cancer risks can be examined. The
consortium could build on the availability of existing cohorts of uranium miners, millers and other
workers (in Belgium, Czech Republic, France, Germany, and United Kingdom) and represented
a unique opportunity to develop a collaborative multidisciplinary research project.
CURE’s main aim was the preparation of a common research protocol, and the verification of
the feasibility of a molecular epidemiology study integrating epidemiology, biology, toxicology
and dosimetry. Three work-packages were defined (epidemiology, dosimetry and biology) and a
further working group on uncertainty was constituted.
The protocols developed by the working groups during the CURE project and the road map to a
future large scale integrated collaborative project in Europe will be presented and discussed.