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ST 1.2 –
Dosimetría externa
ABSORBED DOSE IN FIBROTIC MICROENVIRONMENT MODELS
EMPLOYING MONTE CARLO SIMULATION
Rojas-Calderón, Eva Leticia
1
; Zambrano-Ramírez, Oscar Daniel
2
*;
Azorín-Vega, Erika Patricia
1
; Martínez-Caballero, Eduardo
1
;
Ferro-Flores, Guillermina
1
1
Instituto Nacional de Investigaciones Nucleares. México.
2
Instituto Nacional de Investigaciones Nucleares. Instituto Politécnico Nacional. México.
* Autor Responsable, email: 8zambrano@gmail.com
The presence or absence of fibrosis and yet more, the multimeric and multivalent nature of the
radiopharmaceutical have recently been reported to have an effect on the radiation absorbed
dose in tumor microenvironment models. Fibroblast and myofibroblast cells produce the
extracellular matrix by the secretion of proteins which provide structural and biochemical
support to cells. The reactive and reparative mechanisms triggered during the inflammatory
process causes the production and deposition of extracellular matrix proteins, the abnormal
excessive growth of the connective tissue leads to fibrosis. In this work, microenvironment
(either not fibrotic or fibrotic) models composed of seven spheres representing cancer cells of
10 µm in diameter each with a 5 µm diameter inner sphere (cell nucleus) were created in two
distinct radiation transport codes (PENELOPE and MCNP). The purpose of creating these
models was to determine the radiation absorbed dose to the nuclei of cells, based on previously
reported radiopharmaceutical retain (by HeLa cells) percentages of the
177
Lu-Tyr3-octreotate
(monomeric) and
177
Lu-Tyr3-octreotate-AuNP (multimeric) radiopharmaceuticals. A comparison
in the results between the PENELOPE and MCNP computer codes was done. We found a good
agreement in the results of the codes. The percent difference between the increase
percentages of the absorbed dose in the not fibrotic model with respect to the fibrotic model of
the codes PENELOPE and MCNP was found to be under 1% for both radiopharmaceuticals.